| Test Name: |
MYD88 MUTATION ANALYSIS |
| Test Code: |
2193161 |
| Alias: |
LAB20058
|
| CPT Code(s): |
81305
|
| Preferred Specimen: |
5 mL whole blood |
| Container: |
EDTA (lavender-top) tube |
| Alternate Container: |
Whole blood collected in: Sodium heparin (green-top) or ACD-B (yellow-top) tube • 2 mL bone marrow aspirate collected in an EDTA (lavender-top) tube • Formalin-fixed, paraffin-embedded tissue block • 10 slides tissue submitted in a slide holder • Extracted DNA from CLIA-certified laboratory |
| Minimum Volume: |
2 mL whole blood
0.5 mL bone marrow
6 slides |
| Transport Temperature: |
Room temperature |
| Stability: |
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
Extracted DNA
Room temperature:7 days
Refrigerated: 14 days
Frozen: 1 year |
| Rejection Criteria: |
Received frozen |
| Limitations: |
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes. |
| Schedule: |
Set up: Mon; Report available: 7-14 days |
| Method: |
DNA Sequencing |
| Performing Lab: |
Quest Diagnostics, Chantilly; #91771 |
| Clinical Significance: |
L265P mutation in the MYD88 gene is found in approximately 90% of WaldenstrÖm macroglobulinemia and IgM-expressing lymphoplasmacytic lymphoma (LPL). There is a low incidence of L265P MYD88 mutation in other systemic CD5-negative B-cell lymphoproliferative disorders including atypical chronic lymphocytic leukemia, nodal marginal zone lymphoma (MZL), splenic MZL and mucosa-associated lymphoid tissue (MALT)-type MZL.
This PCR-based DNA pyrosequencing assay sensitively detects the L265P MYD88 mutation and can be used to help diagnose WaldenstrÖm macroglobulinemia or IgM-expressing lymphoplasmacytic lymphoma and to help in stratifying or subclassifying patients with IgM monoclonal gammopathy. |
| Use: |
Updated 02/16/22 |
| Reference Ranges: |
Not detected |
|
The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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| Test Type: |
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