| Test Name: |
MYASTHENIA GRAVIS EVALUATION WITH MUSCLE-SPECIFIC KINASE (MUSK) REFLEX, SERUM |
| Test Code: |
2194528 |
| Alias: |
AChR
LAB16694
MGMR
MuSK
Myasthenia Gravis Antibodies
|
| CPT Code(s): |
86041
*86043 (if appropriate)
*86366 (if appropriate)
|
| Preferred Specimen: |
3 mL serum |
| Container: |
SST |
| Alternate Container: |
Plain red no additive tube |
| Minimum Volume: |
2 mL |
| Collection Instructions: |
Allow specimen to completely clot. Centrifuge for 15 minutes when specimen is clotted or within 2 hours of collection. |
| Transport Temperature: |
Refrigerated |
| Stability: |
Room temperature: 72 hours
Refrigerated: 28 days Frozen: 28 days |
| Rejection Criteria: |
Gross hemolysis, gross lipemia, gross icterus |
| Limitations: |
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration. |
| Additional Information: |
* If acetylcholine receptor (AChR)-binding antibodies are greater than 0.02 nmol/L, then AChR muscle modulating antibody will be performed at an additional charge.
If AChR-binding antibodies are 0.02 nmol/L or less, then muscle-specific kinase (MuSK) autoantibody will be performed at an additional charge.
If unable to report AChR binding antibody due to interfering substances, then AChR muscle modulating antibody will be performed at an additional charge.
If unable to report AChR binding antibody due to interfering substances and AChR muscle modulating antibody is negative, then MuSK autoantibody will be performed at an additional charge. |
| Schedule: |
Set up: Monday-Sunday, reflex testing performance varies
Report Available: 3-11 days |
| Method: |
Radioimmunoassay (RIA), Flow Cytometry, Medical Interpretation |
| Performing Lab: |
Mayo Clinic Dept of Lab Med & Pathology #MGMR |
| Clinical Significance: |
Useful for:
Diagnosing autoimmune myasthenia gravis (MG) in adults and children
Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders Establishing a quantitative baseline value that allows comparison with future levels if weakness is worsening |
| Use: |
Updated: 10/29/2024 |
| Reference Ranges: |
ACh Receptor (Muscle) Binding Ab: < or =0.02 nmol/L
MuSK Autoantibody: 0.00-0.02 nmol/L |
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The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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| Test Type: |
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