Health Lab

Test Name:

CREATININE CLEARANCE, 24-HOUR URINE

Test Code:

2120182

Alias:

LAB818

CPT Code(s):

82575

Test Includes:

Creatinine, 24-Hour Urine

Creatinine, serum or plasma

Creatinine Clearance

Glomerular Filtration Rate

Preferred Specimen:

5 mL urine of a well-mixed, 24-hour collection and

1.0 mL serum

Container:

Amber 24-hour urine plastic container (no preservative) and

SST (gold)

Alternate Container:

24-hour urine: Amber 24-hour urine plastic container with preservative (5 mL 6N HCl or 5 g boric acid)

Blood: Lithium Heparin (lt green)
EDTA (lavender)

Minimum Volume:

1.0 mL urine of a well-mixed, 24-hour collection (no preservative) and

0.3 mL serum or plasma

This volume does not allow for repeat testing.

Collection Instructions:

The collection container must be kept refrigerated or on ice during collection. Instruct patient to void at 8 AM (or 8 PM) and discard the specimen. Then collect all the urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM or 8 PM the following day).

Refer to separate patient instructions for detailed 24-hour urine collection. Record the collection date/time, total volume and patient's height and weight on the specimen container and test requisition.

Blood sample will be collected at the end of the same 24-hour period of urine collection. Allow specimen to completely clot (this can take up to 60 minutes). Centrifuge for 15 minutes. The serum should be physically separated from contact with cells within 2 hours from the time of collection. If the specimen is collected in an anticoagulant tube, centrifuge and transfer plasma into a properly labeled transfer tube within 2 hours of collection.

For patient safety, dropping off specimens requires a full registration process and verification of proper specimen collection.

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 6 days (24-hour urine)

Room Temperature: 7 days (serum or plasma)

Refrigerated: 7 days (serum or plasma)

Rejection Criteria:

No blood drawn

Patient's height and weight not documented

Limitations:

Errors in recording timing of collection period

Loss of a portion of the urine during collection

Including the first void in the timed collection

Urinary retention

Additional Information:

Hydrate the patient by administering a minimum of 600 mL of water. Withhold coffee, tea and drugs on the day of the test. Keep the patient well-hydrated during the urine collection period in order to insure a urine flow rate of 1-2 mL/min or greater. The blood can be collected at any time during the urine collection period . However, blood collection at midpoint of the urine collection period is recommended. Include the patient's height (in feet and inches) and weight (in lbs.) for determining body surface area.

Schedule:

Set up: Daily; Results in 24-48 hours

Method:

Jaffe rate

Clinical Significance:

The creatinine clearance test is used as a measure of glomerular filtration rate.

Use:

Updated 2/28/22

Reference Range Table

Result	Units	Gender	Age	Range
Creatinine	mg/dl	Both	0 Year - 999 Year	0.5-1.2
GFR (African American)	mL/min/1.73 m2	Both	0 Year - 999 Year	61-999
GFR (Others)	mL/min/1.73 m2	Both	0 Year - 999 Year	61-999
Creatinine, 24-hour urine	gm/24hrs	Both	0 Year - 999 Year	0.8-2.0
Creatinine Clearance	mL/min	Female	0 Year - 999 Year	75.0-115.0
Creatinine Clearance	mL/min	Male	0 Year - 999 Year	85.0-125.0

The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.