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Test Name:

HUMAN SEX HORMONE BINDING GLOBULIN

Test Code:

2127600

Alias:

LAB3045
SHBG

CPT Code(s):

84270

Preferred Specimen:

2.0 mL serum

Container:

SST (gold)

Alternate Container:

Lithium Heparin (lt green)

Minimum Volume:

1.0 mL serum or plasma

This volume may not allow for repeat testing.

Collection Instructions:

Allow specimen to completely clot (this can take up to 60 minutes). Centrifuge for 15 minutes. If the specimen is collected in a Li-hep tube, centrifuge for 15 minutes.

Transport Temperature:

Refrigerated

Stability:

Room Temperature: 8 hours

Refrigerated: 7 days
Frozen: 2 months

Schedule:

Set up: Daily; Results in 24-48 hours

Method:

Paramagnetic-particle, chemiluminescent immunoassay

Clinical Significance:

Testosterone, dihydrotestosterone, and estrogens circulate in serum bound to Sex Hormone Binding Globulin (SHBG). SHBG concentrations are increased in pregnancy, hyperthyroidism, cirrhosis, oral estrogen administration, and by certain drugs. Concentrations are decreased by testosterone, hypothyroidism, Cushing's syndrome, acromegaly, and obesity.

Use:

Updated 6/28/24

Reference Ranges:

Age Range Female
0D to < 1M 12.4 to 116 nmol/L
1M to < 1Y 32 to 200 nmol/L
1Y to < 8Y 53.2 to 174 nmol/L
8Y to < 11Y 45.4 to 144 nmol/L
11Y to <13Y 15.9 to 132 nmol/L
13Y to < 19Y 18.1 to 95.8 nmol/L
19Y to < 20Y 9.7 to 207.3 nmol/L
20Y to 46Y 18.2 to 135.5 nmol/L
47Y to 91Y 16.8 to 125.2 nmol/L
> 91Y There is no reference range established for the patient demographic

Age Range Male
0D to < 1M 12.4 to 116 nmol/L
1M to < 1Y 32 to 200 nmol/L
1Y to < 8Y 53.2 to 174 nmol/L
8Y to < 11Y 45.4 to 144 nmol/L
11Y to <13Y 15.9 to 132 nmol/L
13Y to < 19Y 11 to 75.3 nmol/L
>20Y 13.3 to 89.5 nmol/L

The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.

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