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Health Lab Test Code Build Information
Test Name:	NICOTINE AND COTININE, LC/MS/MS, SERUM/PLASMA
Test Code:	2192704
Alias:	90642 LAB414
CPT Code(s):	80323
Preferred Specimen:	1.0 mL serum
Container:	Plain Red (no gel)
Alternate Container:	Plasma collected in: EDTA (lavender or royal blue EDTA) 4.0 mL whole blood collected in: EDTA (lavender)
Minimum Volume:	0.5 mL serum or plasma 2 mL whole blood
Collection Instructions:	Centrifuge specimen and transfer serum into a plastic, screw-capped vial.
Transport Temperature:	Refrigerated
Stability:	Serum and plasma Room temperature: 72 hours Refrigerated: 21 days Frozen: 30 days Whole blood Room temperature: 72 hours Refrigerated: 21 days Frozen: unacceptable
Rejection Criteria:	Gross hemolysis Specimens collected in a SST Frozen whole blood
Limitations:	This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Schedule:	Set up: Mon, Wed, Fri; Report available: 3-5 days
Method:	Chromatography/Mass Spectrometry
Performing Lab:	Quest Diagnostics, Valencia; #90642
Clinical Significance:	This assay is used for the detection of nicotine and cotinine in serum and plasma to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; Its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.
Use:	Updated: 02/27/2026
Reference Ranges:	Nicotine, Serum/Plasma Smoker 2-10 ng/mL Nonsmoker ≤4 ng/mL Cotinine, Serum/Plasma Smoker 16-145 ng/mL Nonsmoker ≤8 ng/mL

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	The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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