Test Name: PORPHOBILINOGEN, QUANTITATIVE, RANDOM URINE
Test Code: 2192800
Alias: LAB19937
CPT Code(s): 84110  
Preferred Specimen:

2 mL urine (no preservative)- protected from light
Container:

BD urine tube no preservative protected from light
Alternate Container:

Amber aliquot tube clearly marked “urine” on the label
Minimum Volume:

1 mL
Collection Instructions:

Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but all samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Transport Temperature:

Refrigerated
Stability:

Room temperature: Unacceptable

Refrigerated: 7 days

Frozen: 30 days
Rejection Criteria:

Not protected from light
Limitations:

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Schedule:

Set up: Tues, Thurs, Sat; Report available: 5-7 days
Method:

Chromatography/Mass Spectrometry
Performing Lab:

Quest Diagnostics, Valencia > SJC; #6329
Clinical Significance: Urinary Porphobilinogen is the first step in the diagnosis of acute porphyrias such as acute intermittent porphyria (AIP). AIP is an autosomal dominant disorder characterized by deficiency of porphobilinogen deaminase. An acute attack usually includes gatrointestinal disturbance and neuropsychiatric disorders.
Use:

Updated: 8/29/23
Reference Ranges:

≤17 Years        <0.36 mg/g creat

≥18 Years        <0.22 mg/g creat

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The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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