| Test Name: |
CHLAMYDIA TRACHOMATIS, RT-PCR, ONESWAB (MDL) |
| Test Code: |
2191062 |
| Alias: |
105
LAB9529
OneSwab
|
| CPT Code(s): |
87491
|
| Test Includes: |
Chlamydia trachomatis by Real-Time PCR (Reflex to azithromycin resistance by Pyrosequencing) (additional CPT/charge may apply) |
| Preferred Specimen: |
OneSwab® |
| Container: |
OneSwab collection device |
| Alternate Container: |
UroSwab
ThinPrep
Whole blood yellow top tube (ACD solution A) |
| Collection Instructions: |
Firmly, yet gently, obtain sample with the OneSwab, rotating it 360o for 10-30 seconds to ensure adequate sampling. When sampling a crusted over lesion, moisten the swab in sterile saline prior to taking the sample. Remove the swab and place into the vial. Snap off the shaft to fit completely in the vial. Be sure the swab fits into the vial prior to capping. Tightly cap the vial. |
| Transport Temperature: |
Room temperature |
| Stability: |
OneSwab®: 15 days
ThinPrep®: 9 days |
| Additional Information: |
Testing of UroSwab specimens for females are applicable for adolescent females who are not candidates for pelvic exams. |
| Schedule: |
Turn-around time: report available in 1-3 days from receipt of specimen at MDL |
| Method: |
Real Time (RT) PCR |
| Performing Lab: |
Medical Diagnostic Laboratories, L.L.C. (MDL); #105 |
| Clinical Significance: |
Chlamydia trachomatis is the causative agent of the disease Chlamydia and is the most common sexually transmitted bacterial agent. In women this bacterium causes cervicitis, urethritis, endometritis and salpingitis. In more complicated cases, C. trachomatis infections may result in tubal scarring, infertility, and ectopic pregnancy. In men it causes urethritis and proctatitis. If left untreated, Chlamydia may develop into lymphogranuloma venereum. Other forms of infection also seen are trachoma, the most preventable form of blindness, and conjunctivitis in neonates. Chlamydia trachomatis has also been associated with reactive arthritis (RA), also called Reiter's syndrome, the most common type of inflammatory polyarthritis in young men. C. trachomatis infection is the most common antecedent of RA and accounts for most cases of venereal origin. It is important that proper treatment be initiated for both the patient and infected sexual partners to prevent spread of the disease and reinfection of the patient. Chlamydia trachomatis is typically thought to be easily treated with antibiotics. Previous studies have demonstrated that azithromycin and doxycycline were equally efficacious for the treatment of genital chlamydial infection. Azithromycin is a popular choice of treatment for those patients with unpredictable follow-up or poor treatment compliance since it can be administered as a single dose. However, recent studies suggest that treatment failure may occur in more than 5% of patients due to resistance to azithromycin. This emerging resistance of Chlamydia trachomatis to azithromycin is important when choosing proper antibiotic therapy. MDL can now detect azithromycin resistance in a subset of C. trachomatis positive specimens by Real-Time PCR. Their new assay detects a C. trachomatis to a single point mutation within the 23S rRNA gene of C. trachomatis that confers resistance to azithromycin. In this assay, DNA is extracted from the specimen and subjected to PCR amplification. |
| Use: |
|
|
 |
Health Lab Test Code Build Information
|
|
|
|
The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
|
| Test Type: |
|