Test Name: *RETIRED* IGF BINDING PROTEIN-3 (IGFBP-3)
Test Code: 2192617
Alias: LAB3064
CPT Code(s): 82397   83520  
Preferred Specimen:

1.0 mL serum
Container:

SST (gold)
Alternate Container: Plain red (no gel)
Minimum Volume:
0.2 mL serum (Note: This volume does not allow for repeat testing.)
Collection Instructions:

Allow specimen to completely clot (this can take up to 60 minutes). Centrifuge for 15 minutes. If collected in a plain red no additive tube, transfer serum to a properly labeled aliquot tube.
Transport Temperature: Refrigerated
Stability:

Room temperature: 14 days

Refrigerated: 14 days

Frozen: 90 days
Limitations: Several factors influence IGFBP-3 levels, including age, sexual development, nutrition, and hepatic and renal function. IGFBP-3 increases during early childhood and puberty and then decreases slightly in adult life. Levels of this binding protein decrease during fasting and chronic malnutrition. IGFBP-3 levels are decreased in hepatic failure and diabetes mellitus, but are increased in chronic renal failure.
Additional Information:

IGFBP-3 is the most abundant IGFBP species in circulation and binds 75% to 90% of circulating IGF-I in a ternary complex consisting of IGFBP-3, IGF-I and acid-labile subunit (ALS). IGFBP-3 modulates the activity of IGF-1 and to increase their half lives. It has been postulated that IGFBP-3 is regulated by GH and originates in the liver as low levels were observed in patients with impaired hepatic function.3

IGFBP-3 has historically been used in the investigation of growth hormone deficiency, acromegaly, hypopituitarism and to monitor recombinant GH therapy.4,5 IGFBP-3 is known to modulate the actions of IGFs in circulation as and at the IGF-1 receptor.3 IGFBP-3 has also been shown to exhibit distinct biological effects independent of the IGF/IGF-1 receptor axis.6,7 Recent studies have impaired interaction of IGFBP-3 with a variety of proteins or signaling cascades critical to cell cycle control and apoptosis; however, the actual mechanism of IGFBP-3 action is unclear.6

 
Schedule:

TAT: Results available in 1-3 days from receipt of specimen at LabCorp
Method: Immunochemiluminometric assay (ICMA)
Performing Lab: LabCorp; #140152
Clinical Significance:

The insulin-like growth factor (IGF) system plays a critical role in the growth and differentiation of normal and malignant cells. The components of the IGF system include growth hormone (GH), IGF-I and II, type I and II receptors, IGF binding proteins and proteases. IGF binding proteins were first identified for their high affinity interactions with IGF-I and IGF-II.2
Use: Updated 2/22/22
Reference Ranges:

 

 

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