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Test Name:

ANTI-CYCLIC CITRULLINATED PEPTIDE (CCP), IgG

Test Code:

2122683

Alias:

A-CCP
Anti-Cyclic Citrullinated Peptide
LAB851

CPT Code(s):

86200

Preferred Specimen:

2.0 mL serum

Container:

SST (gold)

Alternate Container:

Lithium Heparin (Lt green)

Minimum Volume:

1.0 mL serum or plasma
This volume may not allow for repeat testing.

Collection Instructions:

Allow specimen to completely clot (this can take up to 60 minutes). Centrifuge for 15 minutes. If the specimen is collected in a tube without a gel barrier, centrifuge and transfer the serum into a properly labeled transfer tube within 2 hours of collection.

Transport Temperature:

Refrigerated

Stability:

Refrigerated: 3 days
Frozen: 1 month at -20C

Rejection Criteria:

Plasma

Limitations:

In patients receiving thereapy with high biotin doses (i.e.> 5mg/day), no sample should be taken until at least 8 hours after the last biotin administration.

Interference was observed from Rheumatoid factor above concentrations up to 7000 U/mL.

False negative results can occur in patients with hypergammaglobulinemia.

Schedule:

Set up: Daily; Results in 24-48 hours

Method:

IgG-capture test principle

Clinical Significance:

The presence of CCP antibodies, when considered in conjunction with other laboratory and clinical findings, is an aid in the diagnosis of rheumatoid arthritis (RA). Approximately 70% of RA patients are positive for anti-CCP IgG, while only 2% of random blood donors and control subjects are positive.

Use:

Updated 2/28/22

Reference Range Table

Result	Units	Gender	Age	Range
CCP	U/mL	Both	0 Year - 999 Year	0-17

The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.

Reference Range Table

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