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Health Lab Test Code Build Information
Test Name:	MYASTHENIA GRAVIS EVALUATION WITH MUSCLE-SPECIFIC KINASE (MUSK) REFLEX, SERUM
Test Code:	2194528
Alias:	AChR LAB16694 MGMR MuSK Myasthenia Gravis Antibodies
CPT Code(s):	86041 86043 (if appropriate) 86366 (if appropriate)
Preferred Specimen:	3 mL serum
Container:	SST
Alternate Container:	Plain red no additive tube
Minimum Volume:	2 mL
Collection Instructions:	Allow specimen to completely clot. Centrifuge for 15 minutes when specimen is clotted or within 2 hours of collection.
Transport Temperature:	Refrigerated
Stability:	Room temperature: 72 hours Refrigerated: 28 days Frozen: 28 days
Rejection Criteria:	Gross hemolysis, gross lipemia, gross icterus
Limitations:	This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Additional Information:	* If acetylcholine receptor (AChR)-binding antibodies are greater than 0.02 nmol/L, then AChR muscle modulating antibody will be performed at an additional charge. If AChR-binding antibodies are 0.02 nmol/L or less, then muscle-specific kinase (MuSK) autoantibody will be performed at an additional charge. If unable to report AChR binding antibody due to interfering substances, then AChR muscle modulating antibody will be performed at an additional charge. If unable to report AChR binding antibody due to interfering substances and AChR muscle modulating antibody is negative, then MuSK autoantibody will be performed at an additional charge.
Schedule:	Set up: Monday-Sunday, reflex testing performance varies Report Available: 3-11 days
Method:	Radioimmunoassay (RIA), Flow Cytometry, Medical Interpretation
Performing Lab:	Mayo Clinic Dept of Lab Med & Pathology #MGMR
Clinical Significance:	Useful for: Diagnosing autoimmune myasthenia gravis (MG) in adults and children Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders Establishing a quantitative baseline value that allows comparison with future levels if weakness is worsening
Use:	Updated: 10/29/2024
Reference Ranges:	ACh Receptor (Muscle) Binding Ab: < or =0.02 nmol/L MuSK Autoantibody: 0.00-0.02 nmol/L

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	The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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