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Health Lab Test Code Build Information
Test Name:	COLLAGEN TYPE 1 C-TELOPEPTIDE (CTx)
Test Code:	2199394
Alias:	Collagen Type I C-Telopeptide LAB9016
CPT Code(s):	82523
Preferred Specimen:	1.0 mL serum
Container:	Plain Red (no additive/gel)
Minimum Volume:	0.5 mL serum
Collection Instructions:	Patient prep: A minimum of 12 hours fasting is required. Fasting morning collection 8-10 am. (Diurnal variations cause elevated levels at night). Allow specimen to completely clot. Centrifuge for 15 minutes and transfer the separated serum to a plastic transfer tube. Specify specimen type (serum) on transfer tube. Freeze serum as soon as possible.
Transport Temperature:	Frozen
Stability:	Room temperature: 16 hours Refrigerated: 72 hours Frozen: 90 days
Rejection Criteria:	Moderate to gross hemolysis Grossly lipemic Grossly icteric
Additional Information:	Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Schedule:	Set up: Tues-Sat; Report available: 2-4 days
Method:	Immunoassay (IA)
Performing Lab:	Quest Diagnostics, Chantilly; #17406
Clinical Significance:	CTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss.
Use:	Updated: 08/05/2026
Reference Ranges:	Adult Male 18-29 Years 87-1200 pg/mL 30-39 Years 70-780 pg/mL 40-49 Years 60-700 pg/mL 50-68 Years 87-345 pg/mL Adult Female 18-29 Years 60-640 pg/mL 30-39 Years 60-650 pg/mL 40-49 Years 40-465 pg/mL >49 Years Not established Pediatric Male 5-9 Years 574-1849 pg/mL 10-13 Years 519-2415 pg/mL 14-17 Years 435-2924 pg/mL Pediatric Female 5-9 Years 574-1849 pg/mL 10-13 Years 519-2415 pg/mL 14-17 Years 242-1291 pg/mL


	The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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